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Title page for ETD etd-03312010-132747


Type of Document Dissertation
Author Huang, Xi
Author's Email Address xi.huang@vanderbilt.edu
URN etd-03312010-132747
Title Sonic hedgehog signaling in brain development and diseases
Degree PhD
Department Cell and Developmental Biology
Advisory Committee
Advisor Name Title
Vivien A. Casagrande Committee Chair
Chin Chiang Committee Member
Ethan Lee Committee Member
Michael K. Cooper Committee Member
Keywords
  • Sonic hedgehog
  • brain
  • cholesterol
  • patterning
  • choroid plexus
  • cerebellum
  • medulloblastoma
  • holoprosencephaly
Date of Defense 2010-03-23
Availability unrestricted
Abstract
Sonic hedgehog (Shh) signaling regulates important biological processes during embryogenesis and adult homeostasis. Deregulation of this essential signaling pathway can lead to congenital defects and tumorigenesis. In this dissertation I explored the functional role of the cholesterol modification on Shh protein during central nervous system (CNS) patterning, determined previously unappreciated regulation of Shh pathway on hindbrain choroid plexus and cerebellum development, and established a novel mouse model for cerebellar tumor, medulloblastoma. These findings provide us new knowledge of how Shh signaling regulates various CNS organ development, as well as novel insights into the oncogenic processes in Shh-dependent brain tumor.
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  XiHuangDissertationPart2.pdf 3.91 Mb 00:18:06 00:09:18 00:08:08 00:04:04 00:00:20

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