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Title page for ETD etd-03282011-092608


Type of Document Master's Thesis
Author McKinley, Eliot Thomas
URN etd-03282011-092608
Title Use of 18FDG-PET imaging to predict treatment response to IGF-1R/IR targeted therapy in lung cancer
Degree Master of Science
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
H. Charles Manning Committee Chair
Adam Anderson Committee Member
Keywords
  • Treatment Response
  • Medical Imaging
  • PET
  • FDG
  • IGF-1R
Date of Defense 2011-03-28
Availability unrestricted
Abstract
The use of 18FDG-PET imaging to predict treatment response to IGF-1R/IR targeted therapy in mouse models of human lung cancer is presented in this thesis. In vitro cell studies were first conducted to establish sensitivity to treatment with OSI-906 and changes in glucose metabolism in responding cells. In vivo xenograft studies demonstrated that reduced 18FDG-PET correlated with PI3K pathway inhibition and was able to predict tumor response to OSI-906 prior to changes in tumor volume could be ascertained. The in vivo imaging results were validated with molecular correlates. Based upon these results 18FDG-PET imaging appears to serve as a rapid non-invasive marker of IGF-1R/IR inhibition and should be explored clinically as a predictive clinical biomarker in patients undergoing IGF-1R/IR-directed cancer therapy.
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