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Title page for ETD etd-03262013-124650


Type of Document Master's Thesis
Author Davis, Mary Feller
URN etd-03262013-124650
Title Parkinson Disease Loci in the Mid-Western Amish
Degree Master of Science
Department Interdisciplinary Studies: Applied Statistics
Advisory Committee
Advisor Name Title
Jonathan L. Haines Committee Member
Marylyn Ritchie Committee Member
Scott Williams Committee Member
Keywords
  • parkinson disease
  • Amish
  • genetics
  • linkage
  • association
Date of Defense 2013-03-26
Availability unrestricted
Abstract
Previous evidence has shown that Parkinson disease (PD) has a heritable component, but only a small proportion of the total genetic contribution to PD has been identified. Genetic heterogeneity complicates the verification of proposed PD genes and the identification of new PD susceptibility genes. Our approach to overcome the problem of heterogeneity is to study a population isolate, the mid-western Amish communities of Indiana and Ohio. We performed genome-wide association and linkage analyses on 798 individuals (31 with PD), who are part of a 4,998 member pedigree. Through these analyses, we identified a region on chromosome 5q31.3 that shows evidence of association (p-value < 1 x 10-4) and linkage (multipoint HLOD = 3.77). We also found further evidence of linkage on chromosomes 6 and 10 (multipoint HLOD 4.02 and 4.35 respectively). These data suggest that locus heterogeneity, even within the Amish, may be more extensive than previously appreciated.
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