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Title page for ETD etd-03252011-131133


Type of Document Dissertation
Author Wang, Hailun
URN etd-03252011-131133
Title TIP-1, a new biomarker for radiotherapy, regulates migration and invasion of human gliomas through Rho GTPases
Degree PhD
Department Cancer Biology
Advisory Committee
Advisor Name Title
Zhaozhong Han Committee Co-Chair
Keywords
  • Imaging
  • Glioma
  • Rho GTPase
  • Invasion
  • Radiation
  • TIP-1
Date of Defense 2011-02-21
Availability unrestricted
Abstract
Cancer targeted imaging plays an important role in cancer diagnosis. It allows us to rapidly evaluate tumor responses to certain treatments. Peptide-based imaging probes have been widely used in cancer targeted imaging. With the development of phage display technology, a great number of peptides have been identified specifically targeting to tumor cells in vitro and in vivo. However, due to peptides small size and relatively low binding affinity, it is difficult to identify the target of peptides. This thesis research is focusing on: i). identifying the target of specific peptide HVGGSSV, which bind to radiation responsive tumors, by utilizing several affinity purification techniques especially the phage display screening; and validating the target as a marker for evaluation of radiation treatment; ii). exploring the biological functions of the targeting protein.
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