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Title page for ETD etd-03232010-175326


Type of Document Dissertation
Author Zhang, Xi
Author's Email Address xi.zhang@vanderbilt.edu
URN etd-03232010-175326
Title Beta1 integrin in kidney development
Degree PhD
Department Cancer Biology
Advisory Committee
Advisor Name Title
Vito Quaranta Committee Chair
Ambra Pozzi Committee Member
Raymond C. Harris Committee Member
Roy Zent Committee Member
Keywords
  • kidney development
  • branching morphogenesis
  • integrin
  • UUO
  • glomerular filtration barrier
  • growth factor
  • podocyte
Date of Defense 2010-02-23
Availability unrestricted
Abstract
The major goal of this thesis is to examine the role of beta1 integrin in kidney development. Our results indicate that beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. We found that beta1 integrins can regulate branching morphogenesis during development by mediating growth-factor-dependent signaling in addition to their well-defined role as adhesion receptors. We also demonstrated that â1 integrin expression by podocytes is required for normal development and maintenance of glomerular filtration barrier. Overall, our studies discussed in this thesis proved that beta1 integrin is critical for kidney development. These finding have significantly improved the current knowledge of the role of beta1 integrins and facilitated further in depth investigations.
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