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Title page for ETD etd-03182014-144429


Type of Document Dissertation
Author Collier, Sarah Parker
URN etd-03182014-144429
Title TMEVPG1, a long noncoding RNA within the immune system
Degree PhD
Department Microbiology and Immunology
Advisory Committee
Advisor Name Title
Eric Sebzda Committee Chair
Amy Major Committee Member
Andrew Link Committee Member
Anthony Weil Committee Member
Jim Patton Committee Member
Thomas Aune Committee Member
Keywords
  • lincRNA
  • lncRNA
  • interferon gamma
  • gene regulation
  • noncoding RNA
Date of Defense 2014-02-27
Availability unrestricted
Abstract
Thousands of genes encoding long noncoding RNAs were identified throughout the genome; however, less than 1% of known long noncoding RNAs have been assigned a biologic function. At present, long noncoding RNAs mediate positive or negative regulation target gene transcription within nearly all developmental systems establishing an additional layer of noncoding regulation of protein-coding genes. Within the immune system we identified TMEVPG1, an enhancer lncRNA that contributes to the Th1 differentiation program of key adaptive immune cells resulting in the expression of the pleiotropic cytokine interferon gamma. As with other developmental programs, our results demonstrate that a lncRNA plays an essential role in Th1 cell biology.
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