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Title page for ETD etd-03182008-133115


Type of Document Dissertation
Author Ding, Wei
Author's Email Address wei.ding@vanderbilt.edu
URN etd-03182008-133115
Title Regulation of Naked2 by transforming growth factor-alpha and Wnt signaling
Degree PhD
Department Cell and Developmental Biology
Advisory Committee
Advisor Name Title
Stephen Hann Committee Chair
Ethan Lee Committee Member
James Goldenring Committee Member
Scott Hiebert Committee Member
Keywords
  • Colon (Anatomy) -- Cancer -- Genetic aspects
  • TGF-a
  • Wnt
  • Colorectal cancer
  • Naked2
  • Carcinogenesis -- Molecular aspects
  • Carrier proteins
  • Epidermal growth factor -- Receptors
Date of Defense 2008-03-07
Availability unrestricted
Abstract
Naked family members (Drosophila Naked Cuticle and mammalian Naked1 and Naked2) have been identified as inducible antagonists of canonical Wnt signaling. We previously reported that Naked2, but not Naked1, interacts with the cytoplasmic tail of transforming growth factor ƒÑ (TGFƒÑƒw, thereby coating TGFƒÑ-containing exocytic vesicles and directing these vesicles to the basolateral corner of polarized epithelial cells. We have designated Naked2 a cargo recognition and targeting (CaRT) protein required for TGFƒÑ basolateral cell surface delivery. Despite the importance of its role in both Wnt signaling and TGFƒÑ trafficking, the regulation of Naked2 has not been characterized. Moreover, in vivo roles for Naked2 in these biological processes are largely unknown. To address these deficiencies, I have examined the regulation of Naked2 expression in the context of canonical Wnt signaling and epidermal growth factor receptor (EGFR) signaling, and I have generated a targeted conditional disruption of Naked2 in the mouse.
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