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Title page for ETD etd-03072012-142333


Type of Document Dissertation
Author Jeff, Janina Maria
URN etd-03072012-142333
Title The Genetics of Quantitative Traits Associated with Cardiovascular Disease in African Americans
Degree PhD
Department Human Genetics
Advisory Committee
Advisor Name Title
Scott Williams Committee Chair
Marylyn Ritchie Committee Co-Chair
Alyssa Hasty Committee Member
Dan Roden Committee Member
Dana Crawford Committee Member
Keywords
  • electrocardiographic traits
  • fibrinogen
  • African Americans
  • quantitative traits
Date of Defense 2012-02-14
Availability unrestricted
Abstract
Cardiovascular disease (CVD) is the leading cause of death in most developed countries. In addition to environmental risk factors, such as diet and physical activity, genetic risk factors contribute to the CVD risk. Risk of CVD is not uniformly distributed across populations, as African Americans and Hispanics have more risk factors for CVD compared with European Americans. The use of quantitative traits to identify genetic risk factors is a potentially more powerful, informative and uniform approach compared with the use of binary or qualitative traits (such as CVD case status).

My primary objective is to identify genetic risk factors associated with the regulation fibrinogen/hematological and electrocardiogram (ECG) traits in African Americans. Both fibrinogen/hematological and ECG traits are common clinical characteristics of CVD and have a strong genetic component. The primary objective of this work is to identify genetic risk factors associated with the regulation fibrinogen/hematological and electrocardiogram (ECG) traits in African Americans. Both fibrinogen/hematological and ECG traits are common clinical characteristics of CVD and have a strong genetic component. Using three approaches: candidate gene, genome-wide association studies (GWAS), and testing for genetic interactions (gene-gene and gene-environment); we identify novel and previously identified genetic associations with ECG traits and fibrinogen/hematological traits in African Americans and other global populations.

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