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Title page for ETD etd-01292015-133138


Type of Document Dissertation
Author Olena, Abigail Frances
URN etd-01292015-133138
Title microRNA Regulation of Zebrafish Retinal Development
Degree PhD
Department Biological Sciences
Advisory Committee
Advisor Name Title
Douglas G. McMahon Committee Chair
James G. Patton Committee Member
John S. Penn Committee Member
Keywords
  • miR-216a
  • Notch signaling
  • microRNA
  • sorting nexin 5
  • zebrafish
  • retina
Date of Defense 2014-04-17
Availability unrestricted
Abstract

microRNAs (miRNAs) are small noncoding RNAs that bind the 3’ untranslated regions (UTRs) of mRNA targets and, acting with associated proteins, facilitate translation repression and degradation of target mRNAs. Since their discovery in C. elegans, miRNAs and their accessory proteins have been shown to be conserved throughout phylogeny. miRNAs exert their regulatory functions in myriad biological settings, from development and growth to disease. What follows is a general overview of miRNA discovery, organization, and function, and of the use of the powerful vertebrate developmental biology model organism, zebrafish (Danio rerio), zebrafish retinal development, and an overview of Notch-Delta signaling. The purpose of this dissertation is to examine the role of a specific miRNA, miR-216a, in regulation of the Notch-Delta signaling pathway during zebrafish retinal development.

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